Biomarkers predictive of GSI response in solid tumors
نویسندگان
چکیده
Merck Research Laboratory, Boston MA 02115. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115. Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadephia, PA 19104. Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA 02114. Department of Medicine and Digestive Health Research Center, University of Virginia, Charlottesville, Virginia Charlottesville, VA 22908. Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
منابع مشابه
Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.
UNLABELLED Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2 rearrangements leading to constitutive receptor activation were confined to triple-negative breast cancers (TNBC; 6 of 66 tumors). TNBC cell lines with NOTCH1 rearrangements associated with high levels of activated NOTCH1 (N1-ICD) were sensitive to the gamm...
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Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2 rearrangements leading to con-stitutive receptor activation were confi ned to triple-negative breast cancers (TNBC; 6 of 66 tumors). TNBC cell lines with NOTCH1 rearrangements associated with high levels of activated NOTCH1 (N1-ICD) were sensitive to the gamma-secreta...
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